John Stouffer's Tales of Living with Cogan's Syndrome: Rex M. McCallum, MD

Saturday, January 17, 2009

Rex M. McCallum, MD

Rex M. McCallum, MD

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Rheumatology and Immunology
Associate Medical Director, PDC

Department / Division:
Medicine / Rheumatology and Immunology

Address:
DUMC 2954
Durham, NC 27710

Appointment Telephone:
919-668-7630

Office Telephone:
919-684-8763

Fax Telephone:
919-684-6671

Training:

MD, Vanderbilt University School of Medicine (Tennessee), 1980

Residency:

Internal Medicine, Duke University Medical Center, 1980-1983
Rheumatology, Duke University Medical Center, 1983-1986

Clinical Interests:
Vasculitis, Cogan's syndrome, rheumatoid arthritis, connective tissue disease, inflammatory eye disease and systemic illnesses

Research Interests:
My main research interests remain Cogan's syndrome, inflammatory eye disease, and vasculitis. I maintain a clinical data base of the greater than 50 patients with Cogan's syndrome that have been evaluated by Dr. Barton F. Haynes and me since 1977. Cogan's syndrome is a syndrome of inflammatory eye disease associated with vestibuloauditory dysfunction that is Menierre's-like. The etiology of this unusual illness is felt to be inflammatory and autoimmune. In addition, I am one of two attendings in the Duke Uveitis Clinic with Dr. Glen Jaffe of ophthalmology. We maintain a clinical data base of all patients evaluated in the clinic. We perform clinical trials of medications and new approaches to treating inflammatory eye disese. We use an number of systemic medicines to treat inflammatory eye diseases and evaluate our results.

I am co-principal investigator for my colleague, Dr. E. William St. Clair, on his rheumatoid arthritis trials.

Key words: Cogan's syndrome, vasculitis, inflammatory eye disease, uveitis, rheumatoid arthritis

Representative Publications:
McCallum RM: Cogan's Syndrome. In Current Therapy in Allergy, Immunology and Rheumatology, 5th Edition, pp. 255- 260. Lichtenstein LM, Fauci AS (Editors), Mosby-Year Book, Philadelphia, PA, 1996. (1996)

McCallum RM, Haynes BF: Systemic Necrotizing Vasculitis. In Current Therapy in Allergy, Immunology and Rheumatology, 5th Edition, pp. 241-246. Lichtenstein LM, Fauci AS (Editors), Mosby-Year Book, Philadelphia, PA, 1996. (1996)

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DR. Cogan's Bio David Glendenning Cogan

http://www.whonamedit.com/doctor.cfm/2260.html

http://library.med.utah.edu/NOVEL/Cogan/career/
David Glendenning Cogan

American ophthalmologist, born 1908, Fall River, Massachusets; died 9th September, 1993, Bethesda.

Cogan's sign = Cogan's lid twitch, in patients with myasthenia. When the patient's eyes are directed downward for 10 to 20 seconds and the patient is then instructed to make a vertical saccade back to primary position, the upper eyelid elevates and either slowly begins to droop or else twitches several times before settling into a stable position
Cogan-Reese disease = A syndrome characterized by a matted or smudged appearance to the surface of the iris, unilateral glaucoma in the eyes with multiple peripheral anterior synechiae, multiple nodules of the iris, and ectopic Descemet's membrane.

Cogan's syndrome = Syndrome of interstitial keratitis characterized by abrupt onset of vertigo, tinnitus, and usually rapid development of bilateral deafness.

David Glendenning Cogan was born in Fall River, Massachusetts, where his father was an Episcopal minister. He was introduced to ophthalmology by his mother, herself a practitioner and a pioneering ophthalmologist. He attended local school until 1925, when he enrolled at Dartmouth College, where he combined a collegiate schedule with the first two years of medical school.
Cogan continued his studies at Harvard Medical School, graduating in 1932. He interned at the University of Chicago and underwent specialty training in ophthalmology as a resident at the Massachusetts Eye and Ear Infirmary in Boston. He then went abroad to obtain further experience in Switzerland, Germany and Holland as a Mosely travelling fellow.
Already in 1934 he succeeded his old mentor Frederick Verhoeff (1874-1968) as director of the Howe Laboratory of Ophthalmic Research, and he became Senior Surgeon at the Infirmary. During Cogan's 30-year stewardship the Howe Laboratory was to have a tremendous influence on ophthalmic research.
In the years between 1955 and his retirement Cogan was Henry Williams Professor of Ophthalmology at the eye clinic of the Harvard Medical School university hospital.
Following his mandatory retirement in 1973, aged 65 years, Cogan moved to the National Institutes of Health, where he continued his research activities. Despite his age, the tempo of his work continued unabated and he often put in 10-hour days and 6-day weeks.
David Cogan in a fruitful way has encouraged the cooperation between clinicians and scientists of basic research. He initiated and established the ophthalmological courses of basic science, now a part of specialty training at almost every medical faculty in the USA. He also introduced regular appointments for basic research scientists at the eye clinic of Harvard, thus facilitating the cooperation between scientist and clinician, setting an example to all major eye clinics in the USA. The fruitful research climate at his institution has resulted in several of the scientists at Howe Laboratory receiving more honorary awards than those of any other eye research laboratory.
Scientifically David Cogan has been very productive, working in many areas of ophthalmology. As a pathologist he was with the first group of American medical men going to Hiroshima to examine the effect of radiation following the atomic explosion. Through his studies of radiation cataracts he became one of the foremost in this area. He also contributed to the development of relationships between American and Japanese Ophthalmologists. He was one of the first ophthalmologists to visit Germany after the Second World War in an effort to "heal the wounds" and re-establish personal contacts between ophthalmologists in Germany and the USA. When, in his eighties, he was invited to be a lecturer of honour with the association of German ophthalmologists, and rendered his lecture in German.
It is in neuroophthalmology that David Cogan is internationally best known. Already in 1948 he published Neurology of the Ocular Muscles, a book later to go through several editions. The book contains a survey of various forms of nystagmus still worth reading.
David Cogan was an influential teacher, cherished by his countless student, of which several have become prominent. He believed the essence of investigation was originality, curiosity, and perseverance, and fostered that spirit in the talented clinicians and basic scientists he recruited to Howe. Despite his great workload Cogan found time for his family and friends. His home in the city or in the countryside at Lake Michigan were meeting places for scientists in ophthalmology.
During his long career Cogan has received many awards. Among them are the Warren Prize in 1944, Proctor's Award 1954, the Mackenzie medal in 1968, the Research to Prevent Blindness Award 1969 and the Gonin Medallion 1974. In 1985 he was honoured by the dedication of the David G. Cogan Library at the National Eye Institute. His name also lives on in the Cogan Ophthalmic History Society and the David Glendenning Cogan Professorship of Ophthalmology, Harvard Medical School.
During the years 1960 to 1966 he was editor-in-chief of Archives of Ophthalmology, and a member of the editorial staff of Graefe's Archive for Clinical and Experimental Ophthalmology since 1972.
"So great have been Dr. Cogan's achievements in all three areas – research, patient care and education – that he, more than anyone else, is credited with transforming the field of ophthalmology from a branch of surgery into a medical speciality at the forefront of science." Address at the dedication of the David G. Cogan Library at the National Eye Institute.
"To have such a seminal influence on your field is given to very few people ... how a man could by virtue of his mental agility, skills, and kindness catapult to the top remains an example and a lesson." Frederick A. Jakobiec, MD
"My connection with other entities to which you refer were similarly chance observations during a career, now coming to a close, in which I had an unusually favourable academic position. They were modest contributions that have reflected undue credit to me because of the eponymic designation. If, and when, their etiologic origins are clarified they should be classified by a more appropriate terminology." This letter, written in his own hand, illustrates Cogan's humble attitude to his own career.Cogan was a busy medical author, writing more than 500 articles and several books.
The Howe Laboratory of Ophthalmology at Harvard Medical School, the Massachusetts Eye and Ear Infirmary, and the National Eye Institute. 1990, 256 pages.
References:
Cogan DG: Myasthenia gravis: A review of the disease and a description of lid twitch as a characteristic sign. Arch Ophthalmol 74:217–221, 1965.
Cogan DG, Reese AB: A syndrome of iris nodules, ectopicDescemet's membrane, and unilateral glaucoma. Doc Ophthalmol 26:424, 1969.

Posted by John Stouffer at 11:59 PM

John Stouffer's Tales of Living with Cogan's Syndrome

Saturday, January 17, 2009

Rex M. McCallum, MD

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